Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lucka, L.; Krause, M.; Danker, K.; Reutter, W.; Horstkorte, R.
    Primary structure and expression analysis of human UDP-N-acetyl-glucosamine-2-epimerase/N-acetylmannosamine kinase, the bifunctional enzyme in neuraminic acid biosynthesis (1999), FEBS Lett., 454, 341-344.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.60 medicine clinical relevance of the enzyme in the basic defect in sialuria Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.60 cDNA cloned and sequenced, expressed in Escherichia coli HB101 or INValphaF' Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.1.3.14 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.1.60 79000
-
 assembles to dimer or hexamer Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.1.3.14 additional information Homo sapiens key enzyme for biosynthesis of N-acetylneuraminate is the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, catalyzing the first two steps of the biosynthesis in the cytosol ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.60 Homo sapiens Q9Y223 human cell lines promyeolytic leukaemia HL-60, HeLa S3, chronic myelogenous leukaemia K-562, lymphoblastic leukaemia MOLT-4, Burkitt's lymphoma Raji, colorectal adenocarcinoma SW480, lung carcinoma A549 and melanoma G361
-
5.1.3.14 Homo sapiens Q9Y223
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.60 HeLa-S3 cell
-
 Homo sapiens
-
2.7.1.60 HL-60 cell
-
 Homo sapiens
-
2.7.1.60 K-562 cell
-
 Homo sapiens
-
2.7.1.60 liver
-
 Homo sapiens
-
2.7.1.60 placenta
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.60 additional information UDP-GlcNAc 2-epimerase and ManNAc kinase are parts of one bifunctional enzyme, catalyzes the first 2 steps in N-acetylneuraminic acid biosynthesis Homo sapiens ?
-
 ?
5.1.3.14 additional information key enzyme for biosynthesis of N-acetylneuraminate is the bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase, catalyzing the first two steps of the biosynthesis in the cytosol Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.60 dimer
-
 Homo sapiens
2.7.1.60 hexamer
-
 Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.1.60 EC 5.1.3.14/EC 2.7.1.60
-
 Homo sapiens
2.7.1.60 UDP-GlcNAc-epimerase/ManNAc kinase
-
 Homo sapiens
5.1.3.14 More bifunctional enzyme UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase Homo sapiens